Support design of the in-vitro experiments of CYBERNETIC DIALYSIS.
Perform the in-vitro component of CYBERNETIC DIALYSIS experiment in our GLP-qualified lab.
Develop and validate pharmacokinetic models for human (healthy or patients) without concomitant dialysis.
Integrate virtual dialysis component with specific parameters optimized for the drug of interest obtained from the in-vitro experiment into the human pharmacokinetic model.
Simulate pharmacokinetics of drug of interest with clinical doses in the presence and absence of concomitant dialysis and assess the effect of dialysis on drug exposure.
Provide guidance for dosing, dose adjustment and suitability of dialysis methods when dialysis is concomitantly administered.
